Promethazine Indicators and indications of overdosage with promethazine vary from gentle despair on the central nervous procedure and cardiovascular technique to profound hypotension, respiratory despair, unconsciousness and unexpected death.
Right before getting this medication, notify your medical professional or pharmacist Should you be allergic to promethazine or to dextromethorphan; or to every other phenothiazines (like prochlorperazine); or In case you have another allergies.
Small children 12 to 18 several years of age—Use and dose have to be determined by your health care provider. Young children young than 12 several years of age—Shouldn't be used in these individuals. Missed Dose For those who pass up a dose of the medication, skip the skipped dose and go back to your frequent dosing agenda. Do not double doses.
Acute or extreme bronchial asthma within an unmonitored setting or in absence of resuscitative equipment. (4)
Promethazine hydrochloride and codeine phosphate must be supplied to your pregnant female only if Obviously needed.
Pregnancy Assessments: Diagnostic pregnancy exams depending on immunological reactions concerning HCG and anti-HCG could result in Untrue-damaging or Phony-beneficial interpretations.
Discontinuation of a concomitantly made use of cytochrome P450 2D6 inhibitor may possibly end in a minimize in codeine plasma concentration and an increase in Lively metabolite morphine plasma focus which could raise or lengthen adverse reactions and should result in probably fatal respiratory melancholy.
The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are intricate, requiring watchful thought of the consequences around the dad or mum drug, codeine, as well as the Lively metabolite, morphine.
The combination of promethazine hydrochloride and codeine phosphate need to be utilized with warning in pediatric individuals 6 a long time and more mature (see Warnings-Use in Pediatric Individuals).
Negative effects that usually tend not to have to have health-related consideration (report back to your care crew if they proceed or are bothersome):
Don't acquire any benzodiazepines or medicines that may cause drowsiness or sleepiness during treatment method with Promethazine Hydrochloride and Codeine Phosphate Oral Remedy. Inquire your healthcare company for a summary of these medicines if You aren't confident.
Respiratory melancholy leading to arrest, coma, and Loss of life has occurred with the use of codeine antitussives in younger kids, particularly within the Promethazine codeine syrup less than-1-12 months infants whose capability to deactivate the drug is not really thoroughly created.
This isn't a whole list of achievable Uncomfortable side effects. Should you observe other Unwanted effects not outlined above, contact your physician or pharmacist.
Overdosage: If you're thinking that you have got taken a lot of of this medication Make contact with a poison control center or emergency home without delay.